Susceptibility to leprosy is associated with M-ficolin polymorphisms.

doi:10.1007/s10875-012-9770-4

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Article

Susceptibility to leprosy is associated with M-ficolin polymorphisms.

Journal of clinical immunology - 1 Jan 2013

Boldt Angelica B W, Sanchez Maria Iolanda N, Stahlke Ewalda R S, Steffensen Rudi, Thiel Steffen, Jensenius Jens C, Prevedello Flávia Costa, Mira Marcelo Távora, Kun Jürgen F J, Messias-Reason Iara J T

Abstract excerpt

PURPOSE: Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficolin levels and for modulating leprosy susceptibility. METHODS: We genotyped rs2989727 (-1981 G >...

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PMID: 22941510
DOI: 10.1007/s10875-012-9770-4

Genes

FCN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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