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Article

Factors influencing midazolam hydroxylation activity in human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2006

He Ping, Court Michael H, Greenblatt David J, von Moltke Lisa L

Abstract excerpt

The cytochrome P450 3A (CYP3A) subfamily (mainly CYP3A4 and CYP3A5) is responsible for metabolizing approximately half of currently marketed drugs, but with considerable interindividual variability in expression and function. To investigate factors contributing to this variability, rates of midazolam (MDZ) 1'-hydroxylation and CYP3A4 and CYP3A5 protein content were determined using a set of 54 human liver...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

Share to Hydroxylation

Share to Microsomes, Liver

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Source

Identifiers

PMID: 16638818
DOI: 10.1124/dmd.105.008904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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