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Article

Association of genotypes of the CYP3A cluster with midazolam disposition in vivo.

The pharmacogenomics journal - 1 Oct 2009

Miao J, Jin Y, Marunde R L, Gorski C J, Kim S, Quinney S, Radovich M, Li L, Hall S D

Abstract excerpt

The genes that encode for CYP3A4 and CYP3A5 are located in the same region (CYP3A cluster) on chromosome 7. Midazolam (MDZ) is a substrate for both CYP3A4 and CYP3A5. We hypothesize that MDZ disposition in vivo is associated with genotypes of the CYP3A cluster. A meta-analysis of the pharmacokinetic (PK) parameters from seven clinical trials was carried out, in which MDZ was administered both intravenously and...

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Identifiers

PMID: 19506580
DOI: 10.1038/tpj.2009.21
PMCID: PMC2749890

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Source receipt: pubmed, retrieved 7 Sept 2026.

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