Article
Midazolam Intoxication in a Premature Neonate.
Clinical therapeutics - 1 May 2020
Endo Mio, Hirano Ryohei, Shibasaki Hiromi, Yokokawa Akitomo, Furuta Takashi, Abe Kurumi, Morita Koji, Tanaka Sachiko, Hirano Toshihiko, Sakurai Motoichiro, Mizuno Katsumi
Abstract excerpt
PURPOSE: We report the case of a male neonate with a respiratory disorder who developed adverse cardiorespiratory symptoms after the continuous infusion of midazolam. METHODS: To clarify the cause of cardiogenic shock, we performed whole exome sequencing and screened relative single-nucleotide variants of 2 cytochrome P450 (CYP) isoforms, CYP3A4 and CYP3A5, which play a dominant role in the metabolic elimination...
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