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Article

Impact of the CYP3A5 genotype on midazolam pharmacokinetics and pharmacodynamics during intensive care sedation.

European journal of clinical pharmacology - 1 Dec 2007

Fromm Martin F, Schwilden Helmut, Bachmakov Iouri, König Jörg, Bremer Frank, Schüttler Jürgen

Abstract excerpt

OBJECTIVE: Information is lacking on whether the CYP3A5 genotype affects the disposition and effects of midazolam during the long-term intensive care sedation of patients. This study was undertaken to estimate whether the CYP3A5 genotype can explain a relevant portion of pharmacokinetic interindividual variability. METHODS: We determined the CYP3A5 genotype in 71 Caucasian patients who underwent long-term...

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Source

Identifiers

PMID: 17786417
DOI: 10.1007/s00228-007-0365-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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