Article
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.
Molecular psychiatry - 1 Jul 2016
Vélez J I, Lopera F, Sepulveda-Falla D, Patel H R, Johar A S, Chuah A, Tobón C, Rivera D, Villegas A, Cai Y, Peng K, Arkell R, Castellanos F X, Andrews S J, Silva Lara M F, Creagh P K, Easteal S, de Leon J, Wong M L, Licinio J, Mastronardi C A, Arcos-Burgos M
Abstract excerpt
Alzheimer's disease (AD) age of onset (ADAOO) varies greatly between individuals, with unique causal mutations suggesting the role of modifying genetic and environmental interactions. We analyzed ~50 000 common and rare functional genomic variants from 71 individuals of the 'Paisa' pedigree, the world's largest pedigree segregating a severe form of early-onset AD, who were affected carriers of the fully penetrant...
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