Article
Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex.
Cell reports - 23 Feb 2021
Lin Lin, Shi Yingdong, Wang Mengli, Wang Chao, Lu Qing, Zhu Jinwei, Zhang Rongguang
Abstract excerpt
Stereocilia, the mechanosensory organelles on the apical surface of hair cells, are necessary to detect sound and carry out mechano-electrical transduction. An electron-dense matrix is located at the distal tips of stereocilia and plays crucial roles in the regulation of stereocilia morphology. Mutations of the components in this tip complex density (TCD) have been associated with profound deafness. However, the...
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