Article

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins

2024-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Protocadherin-15 is a core protein component of inner-ear hair-cell tip links pulling on transduction channels essential for hearing and balance. Protocadherin-15 defects can result in non-syndromic deafness or Usher syndrome type 1F (USH1F) with hearing loss, balance deficits, and progressive blindness. Three rationally engineered shortened versions of protocadherin-15 (mini-PCDH15s) amenable f...

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Literature Corpus work: be874a9b-ef08-57ae-b4ac-50a5c5420d38
DOI: 10.1101/2024.06.16.599132

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