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Article

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

Nature - 6 Sept 2007

Kazmierczak Piotr, Sakaguchi Hirofumi, Tokita Joshua, Wilson-Kubalek Elizabeth M, Milligan Ronald A, Müller Ulrich, Kachar Bechara

Abstract excerpt

Hair cells of the inner ear are mechanosensors that transduce mechanical forces arising from sound waves and head movement into electrochemical signals to provide our sense of hearing and balance. Each hair cell contains at the apical surface a bundle of stereocilia. Mechanoelectrical transduction takes place close to the tips of stereocilia in proximity to extracellular tip-link filaments that connect the...

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Source

Identifiers

PMID: 17805295
DOI: 10.1038/nature06091

Genes

PCDH15
CDH23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.PMID 17805295Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

Cadherins and mechanotransduction by hair cells.Semantic proximity Read ↗

Harmonin mutations cause mechanotransduction defects in cochlear hair cells.Semantic proximity Read ↗

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.Semantic proximity Read ↗

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.Semantic proximity Read ↗

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.Semantic proximity Read ↗

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.Semantic proximity Read ↗

Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.Semantic proximity Read ↗

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.Semantic proximity Read ↗

Hair cells, plasma membrane Ca²⁺ ATPase and deafness.Semantic proximity Read ↗

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.Semantic proximity Read ↗

Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.Semantic proximity Read ↗

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