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Article

Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2024

Villasante Camila M, Deng Xinyue, Cohen Joel E, Hudspeth A J

Abstract excerpt

Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted to the channels and thus changes their probability of opening. Each tip link comprises four molecules: a dimer of protocadherin 15 (PCDH15) and a dimer of cadherin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39298473
DOI: 10.1073/pnas.2404829121
PMCID: PMC11459131

Genes

PCDH15

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.PMID 39298473Read ↗

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.Semantic proximity Read ↗

A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.Semantic proximity Read ↗

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.Semantic proximity Read ↗

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 ProteinsSemantic proximity Read ↗

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.Semantic proximity Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and DeafnessSemantic proximity Read ↗

The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells.Semantic proximity Read ↗

Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.Semantic proximity Read ↗

Cadherins and mechanotransduction by hair cells.Semantic proximity Read ↗

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.Semantic proximity Read ↗

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