Article

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

2021-07-10

Abstract excerpt

<h4>SUMMARY</h4> The assembly and maintenance of actin-based mechanosensitive stereocilia in the cochlea is critical for lifelong hearing. Myosin-15 (MYO15) is hypothesized to modulate stereocilia height by trafficking actin regulatory proteins to their tip compartments, where actin polymerization must be precisely controlled during development. We identified a mutation (p.D1647G) in the MYO15 motor-domain that i...

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Literature Corpus work: aa1df065-5532-50a4-a759-7c17400527d5
DOI: 10.1101/2021.07.09.451618

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