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Article

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2026

Liang Xiaoping, Pathak Roshan, Qiu Xufeng, Dillard Lucas, Twomey Edward C, Müller Ulrich

Abstract excerpt

Tip links connect the stereocilia of mechanosensory hair cells in the inner ear and transmit force onto mechanotransduction (MET) channels. Tip links consist of protocadherin 15 (PCDH15) and cadherin 23, which assemble into an extracellular filament approximately 150 nm in length. Rare freeze-etched electron microscopy (EM) images have suggested that tip links could be right-handed double helices in vivo, but...

Topics

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Cadherin Related Proteins
Cadherins
Cryoelectron Microscopy
Mechanotransduction, Cellular
Protein Domains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Multimerization

Protein Precursors

Source

Open in PubMed Open full text

Identifiers

PMID: 42263124
DOI: 10.1073/pnas.2607573123
PMCID: PMC13273323

Genes

PCDH15
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.PMID 42263124Read ↗

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