Article

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness

2020-06-19

Abstract excerpt

Cochlear hair cells possess an exquisite bundle of actin-based stereocilia that detect sound. Unconventional myosin 15 (MYO15A) traffics and delivers critical molecules required for stereocilia development and is essential for building the mechanosensory hair bundle. Mutations in the human MYO15A gene interfere with stereocilia trafficking and cause hereditary hearing loss, DFNB3. To understand the molecular mech...

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Literature Corpus work: bb95cea7-3bc5-5411-81c8-5ecf983b8e70
DOI: 10.1101/2020.06.17.155424

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