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Article

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes.

Basic research in cardiology - 17 Feb 2022

Li Ling, Chen Zhifen, von Scheidt Moritz, Li Shuangyue, Steiner Andrea, Güldener Ulrich, Koplev Simon, Ma Angela, Hao Ke, Pan Calvin, Lusis Aldons J, Pang Shichao, Kessler Thorsten, Ermel Raili, Sukhavasi Katyayani, Ruusalepp Arno, Gagneur Julien, Erdmann Jeanette, Kovacic Jason C, Björkegren Johan L M, Schunkert Heribert

Abstract excerpt

The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead, transcriptome-wide association studies (TWAS) identify gene-trait associations, which can be used to prioritize candidate genes in disease-relevant tissue(s). Here, we aimed to systematically identify susceptibility genes for coronary artery disease (CAD) by...

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Identifiers

PMID: 35175464
DOI: 10.1007/s00395-022-00917-8
PMCID: PMC8852935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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