Article
The landscape of accessible chromatin in mammalian preimplantation embryos.
Nature - 30 Jun 2016
Wu Jingyi, Huang Bo, Chen He, Yin Qiangzong, Liu Yang, Xiang Yunlong, Zhang Bingjie, Liu Bofeng, Wang Qiujun, Xia Weikun, Li Wenzhi, Li Yuanyuan, Ma Jing, Peng Xu, Zheng Hui, Ming Jia, Zhang Wenhao, Zhang Jing, Tian Geng, Xu Feng, Chang Zai, Na Jie, Yang Xuerui, Xie Wei
Abstract excerpt
In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed gametes to a totipotent state during preimplantation development. However, the global chromatin landscape and its dynamics in this period remain unexplored. Here we report a genome-wide map of accessible chromatin in mouse preimplantation embryos using an improved assay for transposase-accessible chromatin with high...
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