Article
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.
Developmental cell - 20 Jul 2010
Zhang Nailing, Bai Haibo, David Karen K, Dong Jixin, Zheng Yonggang, Cai Jing, Giovannini Marco, Liu Pentao, Anders Robert A, Pan Duojia
Abstract excerpt
The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of the Hippo kinase cascade are less well defined, especially in mammals. Using conditional knockout mice, we demonstrate that...
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