Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.

Biochemistry - 27 Apr 2010

Gravel Michel, Iliescu Alexandra, Horth Cynthia, Apuzzo Sergio, Gros Philippe

Abstract excerpt

Loop-tail (Lp) mice show a very severe neural tube defect (craniorachischisis) caused by mutations in the Vangl2 gene (D255E, S464N). Mammalian Vangl1 and Vangl2 are membrane proteins that play critical roles in development such as establishment of planar cell polarity (PCP) in epithelial layers and convergent extension movements during neurogenesis and cardiogenesis. Vangl proteins are thought to assemble with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anura
Share to Diptera
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fishes

Share to Mice, Mutant Strains

Share to Neural Tube Defects

Share to Spinal Dysraphism

Source

Identifiers

PMID: 20329788
DOI: 10.1021/bi902180m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.PMID 20329788Read ↗

Loss of membrane targeting of Vangl proteins causes neural tube defects.Semantic proximity Read ↗

An expanding role of Vangl proteins in embryonic development.Semantic proximity Read ↗

The loop-tail mouse model displays open and closed caudal neural tube defects.Semantic proximity Read ↗

Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation.Semantic proximity Read ↗

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.Semantic proximity Read ↗

Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.Semantic proximity Read ↗

A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebratesSemantic proximity Read ↗

Contribution of VANGL2 mutations to isolated neural tube defects.Semantic proximity Read ↗

Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila.Semantic proximity Read ↗

Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting.Semantic proximity Read ↗

A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene.Semantic proximity Read ↗

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.