Article
EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.
EMBO reports - 7 Apr 2021
Bearss Jeremiah J, Padi Sathish Kr, Singh Neha, Cardo-Vila Marina, Song Jin H, Mouneimne Ghassan, Fernandes Nikita, Li Yang, Harter Matthew R, Gard Jaime Mc, Cress Anne E, Peti Wolfgang, Nelson Andrew Dl, Buchan J Ross, Kraft Andrew S, Okumura Koichi
Abstract excerpt
Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P-bodies) are critical regulators of these processes. Here, we report that the Pim1 and 3 protein kinases bind to the P-body protein enhancer of mRNA decapping 3 (EDC3) and phosphorylate EDC3 on serine (S)161, thereby modifying P-body assembly. EDC3 phosphorylation is highly...
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