Article
IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC.
Cell reports - 31 May 2016
Ennajdaoui Hanane, Howard Jonathan M, Sterne-Weiler Timothy, Jahanbani Fereshteh, Coyne Doyle J, Uren Philip J, Dargyte Marija, Katzman Sol, Draper Jolene M, Wallace Andrew, Cazarez Oscar, Burns Suzanne C, Qiao Mei, Hinck Lindsay, Smith Andrew D, Toloue Masoud M, Blencowe Benjamin J, Penalva Luiz O F, Sanford Jeremy R
Abstract excerpt
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cells. Using a combination of genome-wide approaches, we have identified 164 direct mRNA targets of IGF2BP3. These transcripts encode proteins enriched for functions...
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