Article

Pro-survival factor EDEM3 confers therapy resistance in prostate cancer

2022-04-19

Abstract excerpt

<title>Abstract</title> <p>Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and important for prostate cancer viability. EDEM3 is a mannosidase that trims mannose from mis-folded glycoproteins, tagging them for degradation through endoplasmic reticulum associated degradation. Here, we find...

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Literature Corpus work: fa989c48-fa68-5152-8efc-6d2b602f03be
DOI: 10.21203/rs.3.rs-1532644/v1

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