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Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT

8 Apr 2022

Abstract excerpt

Prostate cancer (PCa) poses a major public health problem in men. Metastatic PCa is incurable, and ultimately threatens the life of many patients. Mutations in tumor suppressor genes and oncogenes are important for PCa progression, whereas the role of epigenetic factors in prostate carcinogenesis is insufficiently examined. The histone demethylase KDM5C exerts important roles in tumorigenesis. KDM5C has been...

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PMID: 35454801
DOI: 10.3390/cancers14081894

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