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Article

A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.

Molecular and cellular biology - 1 Dec 2007

Tritschler Felix, Eulalio Ana, Truffault Vincent, Hartmann Marcus D, Helms Sigrun, Schmidt Steffen, Coles Murray, Izaurralde Elisa, Weichenrieder Oliver

Abstract excerpt

Members of the (L)Sm (Sm and Sm-like) protein family are found across all kingdoms of life and play crucial roles in RNA metabolism. The P-body component EDC3 (enhancer of decapping 3) is a divergent member of this family that functions in mRNA decapping. EDC3 is composed of a N-terminal LSm domain, a central FDF domain, and a C-terminal YjeF-N domain. We show that this modular architecture enables EDC3 to...

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Source

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Identifiers

PMID: 17923697
DOI: 10.1128/MCB.01506-07
PMCID: PMC2169425

Genes

DCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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