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NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis

10 Mar 2025

Abstract excerpt

BACKGROUND: Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood. METHODS: We integrated cellular analysis,...

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PMID: 40059196
DOI: 10.1186/s13046-025-03343-5

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