Article

NONO directs PKM2-mediated H3T11ph to promote triple-negative breast cancer metastasis by activating SERPINE1 expression

2024-10-29

Abstract excerpt

<title>Abstract</title> Background Emerging evidence has revealed that PKM2 has oncogenic functions independent of its canonical pyruvate kinase activity, serving as a protein kinase that regulates gene expression. However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood. Methods We in...

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Literature Corpus work: 96927746-4d4c-575d-812c-ba8aa830a7d2
DOI: 10.21203/rs.3.rs-5280141/v1

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