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Article

pH-dependent and dynamic interactions of cystatin C with heparan sulfate.

Communications biology - 12 Feb 2021

Zhang Xiaoxiao, Liu Xinyue, Su Guowei, Li Miaomiao, Liu Jian, Wang Chunyu, Xu Ding

Abstract excerpt

Cystatin C (Cst-3) is a potent inhibitor of cysteine proteases with diverse biological functions. As a secreted protein, the potential interaction between Cst-3 and extracellular matrix components has not been well studied. Here we investigated the interaction between Cst-3 and heparan sulfate (HS), a major component of extracellular matrix. We discovered that Cst-3 is a HS-binding protein only at acidic pH. By...

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Identifiers

PMID: 33580179
DOI: 10.1038/s42003-021-01737-7
PMCID: PMC7881039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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