Article

Structural basis for human chondroitin sulfate chain polymerization

2025-03-21

Abstract excerpt

Chondroitin sulfates are complex polysaccharide chains that regulate various biological processes at the cell surface and within the extracellular matrix. Here, we identify four heterodimeric complexes responsible for chondroitin sulfate chain polymerization in humans: CHSY1-CHPF, CHSY1-CHPF2, CHSY3-CHPF and CHSY3-CHPF2. Using a novel in vitro glycosylation assay based on chemo-enzymatically synthesized fluoresce...

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Literature Corpus work: ae9404fe-c8bd-5131-8dcf-3f9625af59c5
DOI: 10.1101/2025.03.21.644485

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