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Article

Low pH-driven folding of WW45-SARAH domain leads to stabilization of the WW45-Mst2 complex.

Journal of biochemistry - 1 Sept 2015

Song Jinsue, Hong Hye Rim, Yamashita Eiki, Park Il Yeong, Lee Soo Jae

Abstract excerpt

The scaffolding protein Salvador (Sav) plays a key role in the Hippo (Hpo) signalling pathway, which controls tissue growth by inhibiting cell proliferation and promoting apoptosis. Dysregulation of the Hippo pathway contributes to cancer development. Since the identification of the first Sav gene in 2002, very little is known regarding the molecular basis of Sav-SARAH mediating interactions due to its...

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Identifiers

PMID: 25814670
DOI: 10.1093/jb/mvv031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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