Article
Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.
The Journal of biological chemistry - 22 Oct 2004
Moon Andrea F, Edavettal Suzanne C, Krahn Joe M, Munoz Eva M, Negishi Masahiko, Linhardt Robert J, Liu Jian, Pedersen Lars C
Abstract excerpt
Heparan sulfate (HS) plays essential roles in assisting herpes simplex virus infection and other biological processes. The biosynthesis of HS includes numerous specialized sulfotransferases that generate a variety of sulfated saccharide sequences, conferring the selectivity of biological functions of HS. We report a structural study of human HS 3-O-sulfotransferase isoform 3 (3-OST-3), a key sulfotransferase that...
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