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Article

Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor.

The Journal of biological chemistry - 25 Mar 1991

Ortega S, Schaeffer M T, Soderman D, DiSalvo J, Linemeyer D L, Gimenez-Gallego G, Thomas K A

Abstract excerpt

Acidic fibroblast growth factor (aFGF) is a broad spectrum mitogen that is stabilized by complexation with heparin and heparan proteoglycans. The monomeric human protein contains 3 reduced cysteine residues of unknown function, the first 2 of which are conserved among all seven known fibroblast growth factors. The influence of these free sulfhydryl groups on the level, stability, and heparin dependence of the...

Topics

Blotting, Western
Cysteine
Fibroblast Growth Factor 1
Heparin
Humans
Hydrogen-Ion Concentration
Mitogens
Mutation
Serine
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1706340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1706340-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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