Article
Characterization and engineering of S100A12-heparan sulfate interactions.
Glycobiology - 20 Jul 2020
Zhang Xiaoxiao, Ong Chihyean, Su Guowei, Liu Jian, Xu Ding
Abstract excerpt
S100A12, an EF-hand calcium-binding protein, can be secreted by a variety of cell types and plays proinflammatory roles in a number of pathological conditions. Although S100A12 has been shown to interact with heparan sulfate (HS), the molecular detail of the interaction remains unclear. Here we investigate the structural basis of S100A12-HS interaction and how the interaction is regulated by the availability of...
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