Article
Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats.
The EMBO journal - 24 Mar 2004
Kvansakul Marc, Adams Josephine C, Hohenester Erhard
Abstract excerpt
Thrombospondins (TSPs) are extracellular regulators of cell-matrix interactions and cell phenotype. The most highly conserved region of all TSPs are the calcium-binding type 3 (T3) repeats and the C-terminal globular domain (CTD). The crystal structure of a cell-binding TSP-1 fragment, spanning three T3 repeats and the CTD, reveals a compact assembly. The T3 repeats lack secondary structure and are organised...
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