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Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics

11 Feb 2021

Abstract excerpt

To unequivocally address their unresolved intimate structures in blood, we scrutinized the size distribution of circulating cell-free DNA (cfDNA) using whole-genome sequencing (WGS) from both double- and single-strand DNA library preparations (DSP and SSP, n = 7) and using quantitative PCR (Q-PCR, n = 116). The size profile in healthy individuals was remarkably homogenous when using DSP sequencing or SSP...

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PMID: 33571170
DOI: 10.1172/jci.insight.144561

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