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Circulating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis

13 Nov 2023

Abstract excerpt

BACKGROUND: Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecular profile of cfDNA remains obscure. To dissect the DNA fragmentation process, we use a human leukemia cell line HL60 undergoing apoptosis to analyze the size distribution of DNA fragments by...

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PMID: 37953260
DOI: 10.1186/s12915-023-01752-6

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