Article
Refined characterization of circulating tumor DNA through biological feature integration.
Scientific reports - 4 Feb 2022
Markus Havell, Chandrananda Dineika, Moore Elizabeth, Mouliere Florent, Morris James, Brenton James D, Smith Christopher G, Rosenfeld Nitzan
Abstract excerpt
Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell-free DNA (cfDNA) of non-tumor origin. To enhance ctDNA detection, recent studies have been focused on understanding the non-random fragmentation pattern of cfDNA. These studies have investigated fragment sizes, genomic position of fragment end points, and fragment end motifs. Although these features have been...
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