Article
Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models.
Scientific reports - 9 Feb 2021
Jablonski Angela Marie, Warren Lee, Usenovic Marija, Zhou Heather, Sugam Jonathan, Parmentier-Batteur Sophie, Voleti Bhavya
Abstract excerpt
ApoEε4 is a major genetic risk factor for Alzheimer's disease (AD), a disease hallmarked by extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). The presence of the ApoEε4 allele is associated with increased Aβ deposition and a role for ApoEε4 in the potentiation of tau pathology has recently emerged. This study focused on comparing the effects of adeno-associated virus...
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