Article
Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model.
Human molecular genetics - 1 Mar 2014
Zhao Wenjuan, Dumanis Sonya B, Tamboli Irfan Y, Rodriguez Gustavo A, Jo Ladu Mary, Moussa Charbel E H, William Rebeck G
Abstract excerpt
Intraneuronal accumulation of β-amyloid (Aβ)42 is one of the earliest pathological events in humans and in animal models of Alzheimer's disease (AD). Apolipoprotein E 4 (APOE4) is the major identified genetic risk factor for late-onset AD, with Aβ deposition beginning earlier in apoE4-positive subjects. To directly determine the effects of APOE genotype on intraneuronal accumulation of Aβ1-42 at the onset of AD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.