Article

Predicting interaction-specific protein–protein interaction perturbations by missense variants with MutPred-PPI

2025-12-23

Abstract excerpt

Disruption of protein–protein interactions (PPIs) is a major mechanism of a variant’s deleterious effect. Computational tools are needed to assess such variants at scale, yet existing predictors rarely consider loss of specific interactions, particularly when variants perturb binding interfaces without significantly affecting protein stability. To address this problem, we present MutPred-PPI, a graph attention net...

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Literature Corpus work: 3ecdddf9-e608-56c6-aa6c-fd534a54a7be
DOI: 10.64898/2025.12.20.695738

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