Article
SARS-CoV-2 evolution during treatment of chronic infection.
Nature - 1 Apr 2021
Kemp Steven A, Collier Dami A, Datir Rawlings P, Ferreira Isabella A T M, Gayed Salma, Jahun Aminu, Hosmillo Myra, Rees-Spear Chloe, Mlcochova Petra, Lumb Ines Ushiro, Roberts David J, Chandra Anita, Temperton Nigel, Sharrocks Katherine, Blane Elizabeth, Modis Yorgo, Leigh Kendra E, Briggs John A G, van Gils Marit J, Smith Kenneth G C, Bradley John R, Smith Chris, Doffinger Rainer, Ceron-Gutierrez Lourdes, Barcenas-Morales Gabriela, Pollock David D, Goldstein Richard A, Smielewska Anna, Skittrall Jordan P, Gouliouris Theodore, Goodfellow Ian G, Gkrania-Klotsas Effrossyni, Illingworth Christopher J R, McCoy Laura E, Gupta Ravindra K
Abstract excerpt
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.