Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.

doi:10.3390/v16030342

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Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.

Viruses - 23 Feb 2024

Fournelle Dominique, Mostefai Fatima, Brunet-Ratnasingham Elsa, Poujol Raphaël, Grenier Jean-Christophe, Gálvez José Héctor, Pagliuzza Amélie, Levade Inès, Moreira Sandrine, Benlarbi Mehdi, Beaudoin-Bussières Guillaume, Gendron-Lepage Gabrielle, Bourassa Catherine, Tauzin Alexandra, Grandjean Lapierre Simon, Chomont Nicolas, Finzi Andrés, Kaufmann Daniel E, Craig Morgan, Hussin Julie G

Abstract excerpt

Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known epitopes and can therefore have an impact on immune escape. Protracted infections in immunosuppressed patients have been hypothesized to lead to an enrichment of such mutations and therefore...

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PMID: 38543708
DOI: 10.3390/v16030342
PMCID: PMC10974702

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