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Article

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.

Proceedings of the National Academy of Sciences of the United States of America - 7 Sept 2021

Andreano Emanuele, Piccini Giulia, Licastro Danilo, Casalino Lorenzo, Johnson Nicole V, Paciello Ida, Dal Monego Simeone, Pantano Elisa, Manganaro Noemi, Manenti Alessandro, Manna Rachele, Casa Elisa, Hyseni Inesa, Benincasa Linda, Montomoli Emanuele, Amaro Rommie E, McLellan Jason S, Rappuoli Rino

Abstract excerpt

To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for seven passages, but, after 45 d, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an...

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Identifiers

PMID: 34417349
DOI: 10.1073/pnas.2103154118
PMCID: PMC8433494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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