Article

High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies

2021-08-08

Abstract excerpt

The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in SARS-CoV-2 convalescent and vaccinated individuals are key determinants of neutralization breadth and, consequently, the genetic barrier to viral escape. Using chimeric viruses and antibody-selected viral mutants, we show that multiple neutralizing epitopes, within and outside the viral receptor binding domain (RBD), are v...

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Literature Corpus work: b1a2f3da-5d7e-5bf3-8fed-7b86ebc867e2
DOI: 10.1101/2021.08.06.455491

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