Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment.

doi:10.1128/mSphere.00480-21

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Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment.

mSphere - 25 Aug 2021

Chen Liang, Zody Michael C, Di Germanio Clara, Martinelli Rachel, Mediavilla Jose R, Cunningham Marcus H, Composto Kaelea, Chow Kar Fai, Kordalewska Milena, Corvelo André, Oschwald Dayna M, Fennessey Samantha, Zetkulic Marygrace, Dar Sophia, Kramer Yael, Mathema Barun, Germer Soren, Stone Mars, Simmons Graham, Busch Michael P, Maniatis Tom, Perlin David S, Kreiswirth Barry N

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) mutations, exhibit reduced in vitro susceptibility to convalescent-phase serum, commercial antibody cocktails, and vaccine neutralization and have been associated with reinfections. The accumulation of these mutations could be the consequence of...

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Identifiers

PMID: 34431691
DOI: 10.1128/mSphere.00480-21
PMCID: PMC8386433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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