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Article

Neutralisation resistance of SARS-CoV-2 spike-variants is primarily mediated by synergistic receptor binding domain substitutions.

Emerging microbes & infections - 1 Dec 2024

Pham Long V, Underwood Alexander P, Binderup Alekxander, Fahnøe Ulrik, Fernandez-Antunez Carlota, Lopez-Mendez Blanca, Ryberg Line Abildgaard, Galli Andrea, Sølund Christina, Weis Nina, Ramirez Santseharay, Bukh Jens

Abstract excerpt

The evolution of SARS-CoV-2 has led to the emergence of numerous variants of concern (VOCs), marked by changes in the viral spike glycoprotein, the primary target for neutralising antibody (nAb) responses. Emerging VOCs, particularly omicron sub-lineages, show resistance to nAbs induced by prior infection or vaccination. The precise spike protein changes contributing to this resistance remain unclear in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39392057
DOI: 10.1080/22221751.2024.2412643
PMCID: PMC11562025

Genes

ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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