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Article

ATF3 drives senescence by reconstructing accessible chromatin profiles

4 Feb 2021

Abstract excerpt

Chromatin organization and transcriptional profiles undergo tremendous reordering during senescence. However, uncovering the regulatory mechanisms between chromatin reconstruction and gene expression in senescence has been elusive. Here, we depicted the landscapes of both chromatin accessibility and gene expression to reveal gene regulatory networks in human umbilical vein endothelial cell (HUVEC) senescence and...

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Share to Advanced biosensing and bioanalysis techniques
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

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PMID: 33539668
DOI: 10.1111/acel.13315

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