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Increased chromatin accessibility underpins senescence

19 May 2025

Abstract excerpt

Senescence is a cellular state induced by various stressors or extracellular signals, but a universal pathway that triggers this process irrespective of the initial stressor has yet to be identified. Recent data indicate that chromatin opening, particularly in the noncoding genome, is a hallmark of cellular senescence. We propose a model in which this increased chromatin accessibility mediated by transcription...

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Share to Epigenetics and DNA Methylation
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PMID: 40387486
DOI: 10.1111/febs.70136

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