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Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars

1 Apr 2023

Abstract excerpt

Although oncogene-induced senescence (OIS) is a potent tumor-suppressor mechanism, recent studies revealed that cells could escape from OIS with features of transformed cells. However, the mechanisms that promote OIS escape remain unclear, and evidence of post-senescent cells in human cancers is missing. Here, we unravel the regulatory mechanisms underlying OIS escape using dynamic multidimensional profiling. We...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 37082139
DOI: 10.1016/j.xgen.2023.100293

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