Article

FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1

2023-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Aging is characterized by changes in gene expression that drive deleterious cellular phenotypes leading to senescence. The transcriptional activation of senescence genes has been mainly attributed to epigenetic shifts, but the changes in chromatin accessibility and its underling mechanisms remain largely elusive in natural aging. Here, we profiled chromatin accessibility in human dermal fibrobla...

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Literature Corpus work: e40e25a1-48ce-5b06-99df-c20cb02fb95b
DOI: 10.1101/2023.05.04.539315

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FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1DOI 10.1101/2023.05.04.539315Read

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