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Article

Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence

1 Dec 2020

Abstract excerpt

Abstract Intron retention (IR) is the least well‐understood alternative splicing type in animals, and its prevalence and function in physiological and pathological processes have long been underestimated. Cellular senescence contributes to individual aging and age‐related diseases and can also serve as an important cancer prevention mechanism. Dynamic IR events have been observed in senescence models and aged...

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PMID: 33274830
DOI: 10.1111/acel.13276

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