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Article

A gene-level methylome-wide association analysis identifies novel Alzheimer's disease genes.

Bioinformatics (Oxford, England) - 4 Aug 2021

Wu Chong, Bradley Jonathan, Li Yanming, Wu Lang, Deng Hong-Wen

Abstract excerpt

MOTIVATION: Transcriptome-wide association studies (TWAS) have successfully facilitated the discovery of novel genetic risk loci for many complex traits, including late-onset Alzheimer's disease (AD). However, most existing TWAS methods rely only on gene expression and ignore epigenetic modification (i.e., DNA methylation) and functional regulatory information (i.e., enhancer-promoter interactions), both of which...

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Identifiers

PMID: 33523132
DOI: 10.1093/bioinformatics/btab045
PMCID: PMC8337007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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