Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modelling preeclampsia: a comparative analysis of the common human trophoblast cell lines

4 Oct 2020

Abstract excerpt

ABSTRACT Preeclampsia remains a challenge without an effective therapy. Evidence supports targetability of soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and soluble endoglin (sEng), which are released excessively from the placenta under ischemic and hypoxic stresses. We compared four trophoblast cell lines, BeWo, Jar, Jeg‐3, and HTR‐8/SVneo, in order to identify a suitable model for drug screening. Cultured...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Pregnancy and preeclampsia studies
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33521587
DOI: 10.1096/fba.2020-00057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modelling preeclampsia: a comparative analysis of the common human trophoblast cell linesPMID 33521587Read ↗

Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult.Semantic proximity Read ↗

Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsiaSemantic proximity Read ↗

Animal Models of Preeclampsia: Mechanistic Insights and Promising TherapeuticsSemantic proximity Read ↗

Oxidative stress-induced impairment of trophoblast function causes preeclampsia through the unfolded protein response pathwaySemantic proximity Read ↗

Evaluation of optimal trophoblastic models to mimic uterine vessel remodeling in human pregnancySemantic proximity Read ↗

Early onset preeclampsia in a model for human placental trophoblastSemantic proximity Read ↗

HTRA1 in Placental Cell Models: A Possible Role in PreeclampsiaSemantic proximity Read ↗

Single-cell sequencing of trophoblasts in preeclampsia and chemical hypoxia in BeWo b30 cells reveals EBI3, COL17A1, miR-27a-5p and miR-193b-5p as hypoxia-response markersSemantic proximity Read ↗

Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery RemodellingSemantic proximity Read ↗

Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migrationSemantic proximity Read ↗

Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation; relevance to preeclampsiaSemantic proximity Read ↗

Transcriptomic profiling in hypoxia-induced trophoblast cells for preeclampsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.